HORDB

ID: hor002664
Uniprot ID: G3MU46
Protein name: NLP-38
Gene name: nlp-38
Organism: Caenorhabditis elegans
Family: NA
Source: animal
Expression: Expressed in the ventral and dorsal nerve cords and ventral nerve cord motor neurons .
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0006935 chemotaxis; GO:0007218 neuropeptide signaling pathway; GO:0007610 behavior
GO CC: GO:0005576 extracellular region

Sequence: SPAQWQRANGLW
Length: 12(107-118)
Propeptide: MQLIHFIVGLAMLISLSLAASDDRVLGWNKAHGLWGKRSVQEASQDKRTPQNWNKLNSLWGKRSASSFDDDYTTENGDDDVTMLYKRSNLSPRFLGRMTFARIPKISPAQWQRANGLWGR
Signal peptide: MQLIHFIVGLAMLISLSLA
Modification: T12 Tryptophan amide
Glycosylation: NA
Mutagenesis: NA

Function: Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002664_AF2.pdb

hor002664_ESM.pdb

Mass:	160995	Formula:	C64H92N20O17
Absent amino acids:	CDEFHIKMTVY	Common amino acids:	AQW
pI:	10.55	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	5
Hydrophobicity:	-101.67	Boman Index:	-2190
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	49.17
Instability Index:	6904.17	Extinction Coefficient cystines:	11000
Absorbance 280nm:	1000

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans